2015, Cilt 28, Sayı 1, Sayfa(lar) 021-026
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Clinicopathological factors related to survival in lung cancer
Umut KEFELİ1, Bala Başak ÖVEN USTAALİOĞLU2, Mahmut Emre YILDIRIM3, Burçak ERKOL2, Dinçer AYDIN3, Nur ŞENER3, Alper SONKAYA1, Özgür AÇIKGÖZ1
1Tıbbi Onkoloji Anabilim Dalı, Tıp Fakültesi, Kocaeli Üniversitesi, Kocaeli, Türkiye
2Tıbbi Onkoloji Kliniği, Haydarpasa Eğitim ve Araştırma Hastanesi, İstanbul, Türkiye
3Tıbbi Onkoloji Kliniği, Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi, İstanbul, Türkiye
Anahtar Kelimeler: Lung cancer, Survival, Clinicopathology

Objective: The increase in incidence and mortality due to lung cancer was related to gender, tumor type and clinical characteristics of the patients. The aim of this study was to evaluate the relationship between clinical and pathological characteristics of our patients related to survival.

Patients and Methods: Medical records of 1031 patients with lung cancer diagnosed between 2005 and 2012 at our institution were retrospectively analyzed.

Results: The most common histological type in women was adenocarcinoma (42.2%) and in men was squamous type lung cancer (41.5%). When the relation of histological type with smoking was analyzed by excluding undefined-non small cell lung cancer, squamous type lung cancer was the most common type (40.7%) in smokers and adenocarcinoma was the most common type (39.8%) in non-smokers and it was statistically significant. The median survival was 12,09 months. In univariate analysis, early age, The Eastern Cooperative Oncology Group Performance Score (ECOG PS) 0-1, weight loss less than 5%, T stage, non-metastatic disease and early stage disease correlated with better survival. In multivariate analyses, good performance score and weight loss affected survival.

Conclusion: In our study, we found that histology types differ between both genders. Smoking also affects histological type. Despite these results, we could not find any statistically significant relationship between gender, histological type of the tumor, smoking and survival.


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