2010, Cilt 23, Sayı 1, Sayfa(lar) 051-055
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REVERSIBLE POSTERIOR LEUCOENCEPHALOPATHY IN AN 11 YEAR OLD MALE CHILD WITH LUPUS NEPHRITIS
Yılmaz Tabel, İlke Mungan Akin, Serdal Güngör, Cemşit Karakurt, Ünsal Özgen
İnönü üniversitesi, Pediatri Anabilim Dalı, Malatya, Türkiye
Keywords: Childhood, Cyclophosphamide, Leucoencephalopathy, Systemic lupus erythematosus

Systemic lupus erythematosus is a chronic inflammatory disease characterized by highly diverse clinical manifestations. The major organ system involvements in childhood systemic lupus erythematosus are similar to those found in adults. Recognizing and reversing secondary causes of central nervous system abnormalities in patients with systemic lupus erythematosus are essential for preventing long term neurologic disability or death.

In this manuscript, we present an 11 year old male followed up in our clinic, who had the very rare involvement and complications of systemic lupus erythematosus in childhood. He developed a reversible posterior leucoencephalopathy after the first dose of cyclophosphamide, but cyclophosphamide therapy was not stopped as there is no clear evidence in the literature related to the role of this drug in reversible posterior leucoencephalopathy. The patient has now recovered.


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